在无创血糖仪前,白俄罗斯驻上海总领事舍甫琴柯·亚历山大饶有兴致地体验了测量。用酒精消毒右手大鱼际,然后将手伸入仪器,短短两三分钟,屏幕上随即显示了两次测量结果并提供相应生活建议。他身旁的白俄罗斯驻华大使切尔维亚科夫不停追问:“检测原理是什么?采购价格是多少?对医护人员有何要求?”并当场索要了瑞金团队发表在《自然—代谢》杂志上的科学论文。
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In 1996, David Deamer and Daniel Branton’s labs at UC Santa Cruz and Harvard collaborated on a paper showing that when an electric current runs through a nanopore, passing purine (A and G) and pyrimidine (T and C) DNA bases through the nanopore disrupted the current to different degrees. While the technique couldn’t yet discriminate between all four bases, the general idea for a new single-molecule sequencing method was there.